Jayna Gronewold led the Tigers with 14 points and Jenna Fabre added a dozen.
"I was happy that our girls played hard the whole game," said Rothsay Head Coach Anita Heier. "We had some really good stretches, but Parkers is just a really solid team that's hard to stop."
Rothsay (2-14) will host Brandon-Evansville on Tuesday night.